| 课程号 |
00333129 |
学分 |
3 |
| 英文名称 |
Drug and Gene Delivery in Biomedicine |
| 先修课程 |
无 |
| 中文简介 |
在构建基于生物材料的药物输运系统以及应用再生医学中药物疗法的语境下，课程将会介绍药物设计、研发和输运等内容。为了突出应用在诸如DNA、RNA、缩氨酸和蛋白质等制药与生物制药领域的工程与化学/生物化学交叉结合，课程将引入多学科交叉融合的概念。课程将会涉及药物的物化性质与其在人体内吸附、代谢、分布、消除的行为及其机理之间的关系。课程将会介绍能提升治理效能、减少药物毒性以促进疾病治疗和组织/器官再生的方法。课程还将会让学生掌握药物输运系统、基因疗法、RNA干扰和组织工程中所用到的基本原则、技术和生物材料。 |
| 英文简介 |
This course will introduce drug design, development, and delivery in the context of creating biomaterial-based delivery systems and applying pharmaceutical therapies in regenerative medicine. An interdisciplinary mix of ideas will be introduced that emphasizes the intersection of engineering and chemistry/biochemistry applied to pharmaceuticals and biopharmaceuticals including DNA, RNA, peptides and proteins. The course will cover the relationship between drug physicochemical properties and fate in our body such as absorption, metabolism, distribution and elimination (ADME) and the mechanism of drug action. Methods will be described to improve the therapeutic efficacy and reduce the toxicity of drugs for the efficient treatment of diseases and regeneration of tissue/organs. The course will also provide students with an understanding of the principles, strategies, and biomaterials used in drug delivery systems, gene therapy, RNA interference (RNAi) and tissue engineering. |
| 开课院系 |
工学院 |
| 通选课领域 |
|
| 是否属于艺术与美育 |
否 |
| 平台课性质 |
|
| 平台课类型 |
|
| 授课语言 |
英文 |
| 教材 |
Drug Delivery: Engineering principles for drug therapy,M. Saltzman,Oxford University Press, New York,2001；
Biomaterials for delivery and targeting of proteins and nucleic acids,Ram I Mahato,CRC Press；
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| 参考书 |
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| 教学大纲 |
To understand the principles, strategies, and biomaterials used in drug and gene delivery systems and to integrate and apply critical considerations in developing advanced drug and gene delivery systems for the treatment of various pathophysiological conditions and repair the injured tissues or organs.
Synopsis
This course will introduce drug design, development, and delivery in the context of creating biomaterial-based delivery systems and applying pharmaceutical therapies in regenerative medicine. An interdisciplinary mix of ideas will be introduced that emphasizes the intersection of engineering and chemistry/biochemistry applied to pharmaceuticals and biopharmaceuticals including DNA, RNA, peptides and proteins. The course will cover the relationship between drug
physicochemical properties and fate in our body such as absorption, metabolism, distribution and elimination (ADME) and the mechanism of drug action. Methods will be described to improve the therapeutic efficacy and reduce the toxicity of drugs for the efficient treatment of diseases and regeneration of tissue/organs. The course will also provide students with an understanding of the principles, strategies, and biomaterials used in drug delivery systems, gene therapy, RNA interference (RNAi) and tissue engineering.
Topics
1. Introduction, core concepts of drug delivery: dose, delivery route, biodistribution
2. Biomaterials in drug delivery
3. Nanotechnology in drug delivery
4. Gene therapy
5. RNA interference (RNAi)
6. Gene delivery vectors and design (viral and non-viral vectors)
7. Controlled drug and gene delivery
8. Targeted drug and gene delivery
课堂讲授 60%
课堂报告、课堂讨论 40%
Midterm exam 30%
Final exam 35%
Journal club/Presentation 20%
Homework/Assignment 10%
Attendance 5%
Total 100%
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| 教学评估 |
Jeoung Soo LEE：
学年度学期：17-18-3，课程班：生物医学中的药物和基因传递1，课程推荐得分：null，教师推荐得分：null，课程得分分数段：80及以下；
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